News

Longevity research, made understandable.

The studies, treatments, tests and regulatory decisions worth knowing about. We explain what changed, why people care, and how strong the evidence really is.

How we report longevity news

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Biological age Randomized trial in people

Six proteomic clocks predicted lower biological age in a lung drug trial

All six clocks read lower in the treated arms of a 42-person trial of an experimental drug for lung fibrosis. The strongest signal came at week 4, and the protein contributing most to it is a regulator of the scarring the drug treats.

Nature Biotechnology 7 minute read Read the report

Change in predicted biological age, in years

  • Placebo
  • 30 mg once daily
  • 30 mg twice daily
  • 60 mg once daily

Four lines from a shared zero at baseline. Placebo rises slightly. The three treated arms fall, the 30 mg twice daily arm reaching about minus 2.6 years at week 4 before returning to about minus 2.1 at week 12.

Group mean change in predicted biological age since baseline, for one of the six clocks, ProtAge. Values from Supplementary Table 4 of the paper, which tabulates what its Figure 3a draws. ProtAge is shown because it registered more significant comparisons than any other clock in this trial, six of nine. The arms do not all behave alike: the twice daily arm is lowest at week 4 and comes back up by week 12, and the 60 mg once daily arm does not.

More reports

Metabolic health Regulatory decision

FDA adds a cardiovascular indication to Mounjaro

The indication covers adults with type 2 diabetes at high risk of a heart attack or stroke. In the four-year trial behind it, tirzepatide and an older drug that already carried a heart indication performed about the same.

FDA 4 minute read Read the report Exercise and muscle Animal study

Lab-grown muscle grafts made aged mice stronger

Small grafts built from the animals' own muscle cells contracted on their own, and the aged mice that received them ran further, gripped harder and had denser bones.

Nature Aging 4 minute read Read the report Biological age Evidence synthesis in people

Newer epigenetic clocks responded more consistently to longevity interventions

Researchers recalculated the same 16 clocks across 51 human intervention studies. Clocks built around mortality risk and the pace of aging moved more reliably than clocks built to estimate chronological age.

Nature Medicine 5 minute read Read the report

Understand the topic

A news item is about one week. These explainers are the background behind each of them, and they are written to still be right in two years.